1. Introduction. Hypopharyngeal carcinoma is relatively rare in all head and neck cancers (approximately 3–5%) [1, 2].The overall worldwide age-standardized incidence rates occur at a rate of 0.8 per 100,000 (1.4 in men and 0.3 in women) in hypopharyngeal cancer []. Results: Two hundred patients were included in the study; 58 were symptomatic for globus pharyngeus pre-operatively, and 80 per cent of these patients' symptoms resolved post-operatively (p ≤0.0001). Patients with histological features of inflammation showed the greatest improvement (p ≤0.0001). Klare P, Meining A, von Delius S, et al. Argon plasma coagulation of gastric inlet patches for the treatment of globus sensation: it is an effective therapy in the long term. Digestion 2013; 88:165. Timon C, O'Dwyer T, Cagney D, Walsh M. Globus pharyngeus: long-term follow-up and prognostic factors. Ann Otol Rhinol Laryngol 1991; 100:351. I have had LPR / reflux for about 5 years and have made the normal lifestyle changes (diet, bed, etc) which reduced symptoms slightly. PPIs do not seem to help so we suspect pepsin rather than acid. The severity of symptoms changes over time with throat “experiences” occuring roughly as follows: No problem (10%) Based on a study made on globus sensation, about a good 45% of 147 healthy people have had experienced this sensation. Stress and episodes of anxiety are linked to such occurrence. It is also said to be common among women.[2] A common misconception is that globus sensation is cancer related. Globus is rarely a symptom of throat cancer. [5] Treatment of Globus pharyngeus. Treatment tries to address the underlying cause of Globus pharyngeus. With reflux, proton pump inhibitors often tried for at least 3-4 weeks though in some people, it may take up to 3-6 months for adequate resolution. With stress, reassurance alone is often sufficient. Background and Objectives Globus pharyngeus is one of the most common symptoms of patients visiting otorhinolaryngology out-patient clinic, and usually long-lasting, difficult to treat, and One of the most common causes of dysphagia is gastroesophageal reflux (GER). GER disease (GERD) has increased in prevalence dramatically over the past 50 years, outstripping even the obesity epidemic, with which it is closely correlated (Lien et al. 2010; He et al. 2010; Tutuian 2011 ). Estimates of prevalence in Western populations exceed 20% .

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